SLA Driven Load Balancing For Web Applications in Cloud Computing Environment

Cloud computing is an emerging topic in the field of parallel and distributed computing. Many IT giants suchas IBM, Sun, Amazon, Google, and Microsoft are promoting and offering various storage and computeclouds. Clouds provide services such as high performance computing, storage, and application hosting.Cloud providers are expected to ensure Quality of Service (QoS) through a Service Level Agreement (SLA)between the provider and the consumer. In this research, we develop a heterogeneous test bed compute cloudand investigate adaptive management of resources for Web applications to satisfy a SLA that enforcesspecific response time requirements. We develop a system on top of EUCALYTPUS framework that activelymonitors the response time of the computed resources assign to a Web application and dynamicallyallocates the resources required by the application to satisfy the specific response time requirements.Keywords: Eucalyptus, SLA, QOS, Virtualization, Minimum Response Time

Evaluation of the effect of solar radiations on the growth of potential water borne and food borne pathogens during solar eclipse

On new moon day when Moon passes between Earth and Sun solar eclipse can be seen from Earth. Although solar eclipse is a fascinating astronomical event, even in today’s fast, modern and civilized life, people have not been able to go away with superstitious beliefs related to outer space activity behind solar eclipse. These misbelieves eventually lead to great socio-economic losses due to discarding of cooked food and drinking water that was exposed to the eclipse directly or indirectly. So considering these misbelieves a study was conducted to see possible biological effects of solar radiations during solar eclipse on bacteria responsible for water borne and food borne diseases. E. coli, S. aureus, B. subtilis, S. typhi, which are known water and food borne pathogens, were exposed to solar radiations throughout the eclipse period. The effect of these radiations on the survival and growth rate of these organisms was assessed by suitable method and compared with that on control day. When such comparison was made, it indicated that there was no statistically significant effect of solar eclipse on the survival and the growth rate of these organisms. Hence, we insist dumping the cooked food or drinking water after solar eclipse should be avoided

Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand.

Opisthorchis viverrini is distinct among helminth infections as it drives a chronic inflammatory response in the intrahepatic bile duct that progresses from advanced periductal fibrosis (APF) to cholangiocarcinoma (CCA). Extensive research shows that oxidative stress (OS) plays a critical role in the transition from chronic O. viverrini infection to CCA. OS also results in the excision of a modified DNA lesion (8-oxodG) into urine, the levels of which can be detected by immunoassay. Herein, we measured concentrations of urine 8-oxodG by immunoassay from the following four groups in the Khon Kaen Cancer Cohort study: (1) O. viverrini negative individuals, (2) O. viverrini positive individuals with no APF as determined by abdominal ultrasound, (3) O. viverrini positive individuals with APF as determined by abdominal ultrasound, and (4) O. viverrini induced cases of CCA. A logistic regression model was used to evaluate the utility of creatinine-adjusted urinary 8-oxodG among these groups, along with demographic, behavioral, and immunological risk factors. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive accuracy of urinary 8-oxodG for APF and CCA. Elevated concentrations of 8-oxodG in urine positively associated with APF and CCA in a strongly dose-dependent manner. Urinary 8-oxodG concentrations also accurately predicted whether an individual presented with APF or CCA compared to O. viverrini infected individuals without these pathologies. In conclusion, urinary 8-oxodG is a robust \u27candidate\u27 biomarker of the progression of APF and CCA from chronic opisthorchiasis, which is indicative of the critical role that OS plays in both of these advanced hepatobiliary pathologies. The findings also confirm our previous observations that severe liver pathology occurs early and asymptomatically in residents of O. viverrini endemic regions, where individuals are infected for years (often decades) with this food-borne pathogen. These findings also contribute to an expanding literature on 8-oxodG in an easily accessible bodily fluid (e.g., urine) as a biomarker in the multistage process of inflammation, fibrogenesis, and infection-induced cancer

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

PRIVACY PRESERVATION ALGORITHM USING EFFECTIVE DATA LOOKUP ORGANIZATION FOR STORAGE CLOUDS

ABSTRACT In the era of cloud computing, many cloud service providers like Amazon, Microsoft, Google, et

Multi-Threaded User Space Network Stack For Intrusion Prevention System

------------------------------------------------------------------Abstract--------------------------------------------------------

Development and characterization of a 3D cone beam tomography system

3D Visualization of the interior of an object has been one of the important goals of NDT, which has many applications. It can be used for examination of defects and cracks in their full three-dimensional perspective and reverse engineering applications. This paper describes the development and characterization of a high dynamic range cooled CCD-based cone beam tomography system for industrial applications and in particular for the NDT of materials used in the nuclear industry. The novel feature of this system is its ability to distinguish minor variations in the attenuation coefficients with very high resolution. The paper also discusses the development of software implementation of Feldkamp formulation for reconstruction, testing with mathematically simulated phantom, and hardware used in the work. The system is characterized in terms of MTF both in the mid-plane and off-midplane are also discussed in this paper. We will present results of experiments conducted on a variety of samples of nuclear and industrial use

Evaluation of the effect of solar radiations on the growth of potential water borne and food borne pathogens during solar eclipse

On new moon day when Moon passes between Earth and Sun solar eclipse can be seen from Earth. Although solar eclipse is a fascinating astronomical event, even in today’s fast, modern and civilized life, people have not been able to go away with superstitious beliefs related to outer space activity behind solar eclipse. These misbelieves eventually lead to great socio-economic losses due to discarding of cooked food and drinking water that was exposed to the eclipse directly or indirectly. So considering these misbelieves a study was conducted to see possible biological effects of solar radiations during solar eclipse on bacteria responsible for water borne and food borne diseases. E. coli, S. aureus, B. subtilis, S. typhi, which are known water and food borne pathogens, were exposed to solar radiations throughout the eclipse period. The effect of these radiations on the survival and growth rate of these organisms was assessed by suitable method and compared with that on control day. When such comparison was made, it indicated that there was no statistically significant effect of solar eclipse on the survival and the growth rate of these organisms. Hence, we insist dumping the cooked food or drinking water after solar eclipse should be avoided